NUMTs in the sponge genome reveal conserved transposition mechanisms in metazoans.

TitleNUMTs in the sponge genome reveal conserved transposition mechanisms in metazoans.
Publication TypeJournal Article
Year of Publication2011
AuthorsErpenbeck D, Voigt O, Adamski M, Woodcroft BJ, Hooper JN, Wörheide G, Degnan BM
JournalMolecular biology and evolution
Volume28
Issue1
Pagination1-5
Date Published2011 Jan
ISSN1537-1719
KeywordsAnimals, Cell Nucleus, DNA Transposable Elements, DNA, Mitochondrial, Evolution, Molecular, Genome, Molecular Sequence Data, Phylogeny, Porifera
Abstract

The transposition of parts of the mitochondrial (mt) genetic material into the nuclear genome (NUMTs) occurs in a wide range of eukaryotes. Here, we show that NUMTs exist for nearly all regions of the mt genome in the demosponge Amphimedon queenslandica, a representative of the oldest phyletic lineage of animals. Because the sponge NUMTs are small and noncoding, and transposed via a DNA intermediate, as in eumetazoans, we infer that the transpositonal processes underlying NUMT formation in contemporary animals existed in their most recent common ancestor. In contrast to most bilaterians, Amphimedon NUMTs are inserted into regions of high gene density. Given the common features of metazoan NUMTs, the reduction in animal mt genome sizes relative to other eukaryotes may be the product of the mt DNA transposition mechanisms that evolved along the metazoan stem.

Alternate JournalMol. Biol. Evol.