Genome sequences of rare, uncultured bacteria obtained by differential coverage binning of multiple metagenomes.

Title	Genome sequences of rare, uncultured bacteria obtained by differential coverage binning of multiple metagenomes.
Publication Type	Journal Article
Year of Publication	2013
Authors	Albertsen M, Hugenholtz P, Skarshewski A, Nielsen KL, Tyson GW, Nielsen PH
Journal	Nature biotechnology
Volume	31
Pagination	533-8
Date Published	2013 Jun
ISSN	1546-1696
Abstract	Reference genomes are required to understand the diverse roles of microorganisms in ecology, evolution, human and animal health, but most species remain uncultured. Here we present a sequence composition-independent approach to recover high-quality microbial genomes from deeply sequenced metagenomes. Multiple metagenomes of the same community, which differ in relative population abundances, were used to assemble 31 bacterial genomes, including rare (
DOI	10.1038/nbt.2579

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