Title | Genome sequences of rare, uncultured bacteria obtained by differential coverage binning of multiple metagenomes. |
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Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Albertsen M, Hugenholtz P, Skarshewski A, Nielsen KL, Tyson GW, Nielsen PH |
Journal | Nature biotechnology |
Volume | 31 |
Pagination | 533-8 |
Date Published | 2013 Jun |
ISSN | 1546-1696 |
Abstract | Reference genomes are required to understand the diverse roles of microorganisms in ecology, evolution, human and animal health, but most species remain uncultured. Here we present a sequence composition-independent approach to recover high-quality microbial genomes from deeply sequenced metagenomes. Multiple metagenomes of the same community, which differ in relative population abundances, were used to assemble 31 bacterial genomes, including rare ( |
DOI | 10.1038/nbt.2579 |
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